ALCOHOL CONTENT DETERMINATION – authorSTREAM Presentation. density, if you have density of your initial product you can estmate and also build a curve using etanol to the mix and know the final density later. If you know the. Two methods are adopted for the estimation of this. In one Traditionally, determination of alcohol in galenicals is carried out by distillation method followed by.

Author: Gok Bralmaran
Country: Chad
Language: English (Spanish)
Genre: Medical
Published (Last): 8 June 2005
Pages: 129
PDF File Size: 4.9 Mb
ePub File Size: 2.35 Mb
ISBN: 221-2-88691-842-7
Downloads: 61246
Price: Free* [*Free Regsitration Required]
Uploader: Migor

Weight readings were made each 30 seconds over a six-minute period demonstrating uniformity of loss over this period.

All the solutions containing free Iodine should be treated with Zinc before the distillation or decolorize with Nathiosulphate followed by a few drops of NaOH. The instrument contains a column of 2mm by 4mm packed with polyethylene glycol. Chromatographic condition Carrier gas Helium or nitrogen Column packing Silica particles coated with polyethylene glycol Detector Flame Ionization Detector Column temperature Temperature of the column is maintained at o C Injection port temperature Temperature of the injection port o C Standard solutions: From the chromatogram obtained, we can calculate the percentage of alcohol as by using the following formula: Glycerin and iodine Glycerin: The instant disinfectant compositions comprise: For example, there may be mentioned Klucel HF and Klucel EF, which are hydroxypropyl cellulose ethers having molecular weights of about 1, and 60, respectively.

The inventor has discovered a method of decreasing evaporation of alcohol skin disinfectants comprising adding alcohol-soluble viscosifying agents to these disinfectants, thereby increasing the exposure time and alcohol concentration of the disinfectant on the skin.

As examples of preferred compositions, the following may be eshimation. You do not have the permission to view this presentation. Two pieces of mounted skin were used for each sample alckhol. Distill whole of the aqueous solution containing brine solution.


Determine peak response ratios.

US5288486A – Alcohol-based antimicrobial compositions – Google Patents

While the molecular weight of the viscosifying agent is not critical, these preferred viscosifying agents are polymers with molecular weights sufficient to produce composition viscosities of at least 40 centipoise, when added to alcohol-based antimicrobial compositions at recommended dosages. The distillate must be clear and not more than slightly cloudy and does not contain more than traces of volatile substances other than alcohol and water.

The preparations that are basic in nature are treated with dilute H 2 SO 4 before distillation and the preparations that are acidic in nature are treated with NaOH solution before distillation. The presentation is successfully added In Your Favorites.

USA – Alcohol-based antimicrobial compositions – Google Patents

Application of Test Organisms: These salts then do not interfere with ethanol evaporation in distillation process. This mixed inoculum was further diluted to give either 10 7 or 10 5 organisms per ml depending upon the test conditions desired.

Additionally, these compositions may contain fragrances, coloring agents, detackifiers such as cetyl lactate and additional antimicrobials without departing from the spirit of this invention. Standardize them by calculating its specific gravity and noting the percentage from the table given in B. The alcohol-soluble viscosifying agent should be added to an alcohol composition at a dosage of from about 0. Bring the temperature at which the procedure was started Add sufficient amount of distilled water to make the volume 50ml.


Compositions having enhanced deposition of a topically active compound on a surface. Take the distillate 2ml less than the original sample. There are two methods for the determination of alcoholic contents.

WordPress Embed Customize Embed. Povidone iodine PVP-I alcohol gel antimicrobial pre-operative skin preparation. Treat the liquids that froth to a troublesome extent during distillation by ; 1- Rendering them strongly acidic with H 3 PO 4H 2 SO 4tannic acid 2- Treating with a slight excess of calcium chloride solution or with a small amount of paraffin or silicon oil before starting the distillation.


Aglenicals uses will become apparent to those skilled in the art and are intended to be within the scope of this invention. Add to it 50ml of brine solution, i. Standardize them by calculating specific gravity and noting the percentage from the table given in B.

The plates were graded to indicate the extent of organism growth in the imprint. Add sufficient amount of distilled water to the distillate to make volume 25ml. In most of the galenical preparations, alcohol is used. Preparation of Pig Skin: More preferably, the viscosifiers produce viscosities of about 50 to about cps in the final compositions. The following examples demonstrate the retardation of alcohol evaporation using viscosifying agents.

Add twice the volume of distilled water. An inert gas such as gallium is used as carrier at a flow rate of about 60ml per minute.

Calculate the specific gravity and note its percentage from the table given in B. X, Y and Z are the ratio of alcohol peak area to the internal standard peak areas glaenicals the standard solution 1, standard solution 2 and the sample respectively.

These examples are not intended to limit the scope of the invention. Volatile acids and bases Render the preparations containing volatile bases slightly acidic with dilute sulphuric acid before distillation If volatile acids are present, render the preparation slightly alkaline with sodium hydroxide test solution Acidifying the bases or alkalinizing the acids causes them to be converted aglenicals ionized form and form salts.